Rho Kinase Inhibitors - Role in Glaucoma and Cornea Practice
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https://doi.org/10.56692/upjo.2023110203Keywords:
cornea, glaucoma, Rho kinase, ROCK inhibitorsDimensions Badge
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Copyright (c) 2023 Dr. Neha Kumari, Prof. M Vanathi
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The rho-kinase pathway has been implicated in the pathogenesis of various ocular disorders like glaucoma, Fuchs cornealAbstract
dystrophy, diabetic retinopathy, diabetic macular edema, age-related macular degeneration (AMD), ROP. ROCK molecules and
the ROCK pathway regulate multiple physiological functions, such as cell contraction, migration, proliferation, angiogenesis,
chemotaxis, neural protection and vasodilatation, mainly via reorganization of the cytoskeleton. Corneal endothelium increases
endothelial cell proliferation and adhesion and decreases endothelium to mesenchyme transformation. Various studies have
demonstrated their safety and efficacy for ophthalmic use. This review highlights the use of ROCK inhibitors in glaucoma and
corneal diseases.
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